Anxiety Disorders (Adult) Research Study
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1. Understanding the Brain & Body Responses Associated with Anxiety Disorders
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Several research studies seek to learn about brain and body responses associated with generalized anxiety disorder.Recruiting adults, ages 18-50, to participate in several outpatient visits to the NIH Clinical Center in Bethesda, Maryland. Eligible participants must have anxiety symptoms, be medically healthy and not currently taking psychiatric medication or abusing alcohol or other substances. Participation includes having psychiatric interviews, psychological testing, brain imaging, medical history and a physical exam. There is no cost for participation or any tests associated with the research. Financial compensation is available for participation. This study enrolls participants locally from within 50 miles of NIH.Call toll free: 1-888-644-2694 (1-888-NIH-ANXI) TTY: 1-866-411-1010, E-mail:anxiety@mail.nih.gov
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Anxiety Disorders (Adult) Research Study
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2. Generalized Anxiety Disorder and Social Anxiety Disorder: Their impact on the processing of social emotional information and instrumental learning
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If you consider yourself to experience more anxiety or are shyer than those around you or have been diagnosed with generalized anxiety disorder or social anxiety disorder, you may be able to participate in this study examining how the brain responds to and analyzes emotional events.
Our goal is to understand what is special about the brain response to emotional events in people with anxiety disorders. We assess brain responses with both computer tasks and brain imaging (functional Magnetic Resonance Imaging; fMRI). Healthy volunteers who have no history of psychiatric or major medical illness will also be enrolled in this study.
To find out if you qualify or for more information, please call (301) 496-5645 or email us at nimhcore@mail.nih.gov.
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Anxiety Disorders (Adult) Research Study
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3. Predictability and Aversive Expectancies in Anxiety Disorders
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If you consider yourself to experience more anxiety than those around you or have been diagnosed with generalized anxiety disorder, social anxiety disorder, panic disorder, or specific phobia, you may be able to participate in this study examining changes in the body and brain that occur during fear and fear learning.
Basic research has identified biological processes that play a key role in fear and anxiety. The present study examines such processes across those with and without elevated levels of anxiety to better understand the biological basis of anxiety disorders. More specifically, we will be assessing changes in heart rate (EKG), muscle activity (EMG), sweat responses (SCR) and respiration that occur during exposure to mildly unpleasant events. Healthy volunteers who have no history of psychiatric or major medical illness will also be enrolled in this study.
To find out if you qualify or for more information, please call (301) 496-5645 or email us at nimhcore@mail.nih.gov.
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Anxiety Disorders (Adult) Research Study
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4. Effects of D-Cycloserine on Treatment in Social Anxiety
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This study examines whether an antibiotic, d-cycloserine (DCS), boosts the effectiveness of cognitive behavior therapy (CBT) for social anxiety. CBT has been shown to be effective for the treatment of social anxiety in children and adults, but even after treatment, approximately 40% may remain diagnosable.
All participants will receive 12 weekly CBT sessions. In addition to receiving the CBT, participants will be randomly assigned (similar to a coin toss) to receive either DCS or a placebo (sugar pill). The pill will be taken 1-2 hours prior to each of the 12 CBT sessions. The pill is taken only on the 12 therapy days. If you are ages 7-55 with a social phobia, you may be eligible for the study.
To find out if you qualify or for more information, please call (301) 496-5645 or email us at nimhcore@mail.nih.gov.
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Anxiety Disorders (Adult) Research Study
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5. NIMH Family Study of Health and Behavior
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The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.
We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors.
To find out if you qualify or for more information, please call 1-877-250-1560 or email at familystudy@mail.nih.gov.
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Autism Spectrum Disorders (Adult) Research Study
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1. Brain Imaging of Autism Biomarker
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This research study seeks to detect and measure an immune biomarker in the brain. Researchers will compare the brain scans of those with Autism to those without Autism.
The causes of autism are not known, but previous research has suggested an association between autism and immune changes in the brain. This study proposes to determine whether the emerging evidence and role of neuroimmune activation (as a biomarker in the brain) will indicate if there are greater immune changes in persons with autism.
This outpatient research study includes 2-4 outpatient visits of 2-6 hours each. There is an initial screening appointment that includes a physical examination, psychological examination, medical history, mood and behavior questions, and blood and urine tests. The research study includes a baseline MRI brain scan, a PET brain scan (with the administration of a drug that attaches to a brain protein), and a follow-up visit to provide a final blood sample. Eligibility criteria includes: adults ages 18-45; a diagnosis of Autism, Asperger Syndrome, or an Autism Spectrum Disorder; and good health (without a serious medical condition.)
There is no cost to participate. Compensation is provided for participation. Transportation may be provided. For information or to find out if you qualify, call: 301-435-8982 (TTY: 1-866-411-1010). Email: autismbrain@mail.nih.gov
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Autism Spectrum Disorders (Adult) Research Study
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2. Brain Imaging Study of Adults with Autism Spectrum Disorders
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This research study investigates the effects of oxytocin and vasopressin on brain activity in adults with Autism Spectrum Disorders using functional magnetic resonance imaging (fMRI).
This outpatient study will be conducted at the NIH Clinical Center in Bethesda, Maryland. There will be an initial screening appointment and 3 visits of about 2.5 hours each. During each visit, participants will receive a nasal spray containing either drug (vasopressin or oxytocin) or placebo (a solution containing no medication). After receiving the nasal spray, participants will be scanned while performing various computer-generated tasks.
Right-handed individuals between 18 and 40 years of age who have been diagnosed with Autism, Asperger Syndrome, or Pervasive Developmental Disorder- Not Otherwise Specified (PDD-NOS) may be eligible to participate. There is no cost for participation. Compensation will be provided. To find out if you qualify or for more information, please call 301-451-7822 (TTY: 1-866-411-1010) or e-mail nimh-asd@mail.nih.gov . National Institute of Mental Health, National Institutes of Health, Department of Health & Human Services
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Bipolar Disorder (Adult) Research Study
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1. Antidepressant (Rapid) Effects of Ketamine
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If you (or someone you know) have been diagnosed with bipolar disorder, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.
If you are 18-65 years of age and have been diagnosed with bipolar disorder and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.
After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov .
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Bipolar Disorder (Adult) Research Study
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2. Riluzole to treat Depression in Bipolar Disorder
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If you (or someone you know) have been diagnosed with bipolar depression or manic-depressive illness, you may be able to participate in our clinical trial designed to decrease symptoms of depression and understand the causes of depression. Specifically, we are testing whether riluzole (FDA approved for ALS also known as Lou Gehrig's disease) a drug that affects glutamate in the brain will improve symptoms of depression. We are also conducting neuropsychological testing in this study.
If you are 18-70 years of age and have been diagnosed with bipolar depression, you may be eligible for an outpatient or inpatient clinical trial of riluzole in bipolar depression.
After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for participation in neuropsychological exams.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov.
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Bipolar Disorder (Adult) Research Study
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3. Evaluations for Treatment and Brain Imaging Studies in Bipolar Depression
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If you or someone you know has Bipolar Disorder and are experiencing depressive symptoms, you may be eligible for participation in research studies being conducted at the National Institute of Mental Health (NIMH).
NIMH researchers are conducting evaluations with individuals between the ages of 18 and 70 for medication studies (standard and novel antidepressants) and brain imaging studies. These evaluations include 1-4 visits, psychiatric interviews, medical history, physical exam, blood and other medical tests. These research studies are conducted in both outpatient and inpatient settings at the NIH Clinical Center in Bethesda, Maryland.
Participants must be free of other serious medical conditions. Research evaluations and medications are provided at no cost. Additionally, we will cover transportation costs from anywhere in the U.S. Compensation is provided for research procedures and brain imaging.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov (TTY: 1-866-411-1010) Atendemos pacientes de habla hispana.
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Bipolar Disorder (Adult) Research Study
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4. Investigating the Genetics of Bipolar Disorder in those affected and their family members
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Researchers are looking for genes that may affect a person's chances of developing bipolar disorder. You can participate in this research study if you are over 18, have a bipolar diagnosis, or have a family member with bipolar disorder.
This study includes a telephone interview (2-4 hours) and a blood sample (blood work from your physician.) The purpose of this study is to identify genes that may contribute to the development of bipolar disorder (manic depression), and related conditions. Bipolar disorder is a common and potentially life-threatening mood disorder. The tendency to develop bipolar disorder can be inherited, but this is poorly understood and probably involves multiple genes.
This study will use genetic markers to map and identify genes that contribute to bipolar disorder. Families and individuals who have the disorder are asked to contribute personal information and a blood sample to an anonymous national database. This information will aid scientists around the world who are working together to develop better treatments for this serious mood disorder.
To find out if you qualify or for more information, please call 1-866-644-4363 or email us at kazubad@mail.nih.gov.
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Bipolar Disorder (Adult) Research Study
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5. NIMH Family Study of Health and Behavior
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The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.
We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors.
To find out if you qualify or for more information, please call 1-877-250-1560 or email at familystudy@mail.nih.gov.
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Depression (Adult) Research Study
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1. Rapid Antidepressant Effects of Ketamine
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If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.
If you are 18-65 years of age and have been diagnosed with major depression (unipolar) and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.
After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov.
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Depression (Adult) Research Study
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2. Depression & Scopolamine
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NIMH researchers are conducting an inpatient or outpatient treatment study to look at how a currently FDA-approved drug, Scopolamine, which is used for motion sickness, can help with depression. In this study, the drug is given intravenously over 7-sessions.
Eligibility criteria: Ages 18-55, currently depressed, not taking medications for at least 3 weeks.
After completion of the study, NIMH will provide short-term follow-up care, and then you will return to the care of your own provider. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States.
To find out if you qualify or for more information, please call 1-877-269-5586 or email us at moodresearch@mail.nih.gov (TTY: 1-866-411-1010). Atendemos pacientes de habla hispana.
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Disease and Treatment Information |
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Depression (Adult) Research Study
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3. Depression & Citalopram
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The scientific aims of the study are to compare blood cell levels of the p11 protein (which affects serotonin receptors) in depressed verses non-depressed individuals. We would like to examine the effect of citalopram, a selective serotonin reuptake inhibitor, on p11 levels in relation to treatment outcome.
This is a 10-12 week outpatient research study in Bethesda, MD. Eligibility Criteria: 18 - 65 years of age; currently in an episode of Major Depressive Disorder or have never experienced depression in the past; and are otherwise medically healthy. Research evaluations and medications are provided at no cost. Local transportation can be provided. After completion of the study, NIMH will provide short-term follow-up care, and then you will return to the care of your own provider.
To find out if you qualify or for more information, please call1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov (TTY: 1-866-411-1010). Atendemos pacientes de habla hispana.
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Disease and Treatment Information |
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Depression (Adult) Research Study
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4. Evaluations for Treatment and Brain Imaging Studies in Unipolar Depression
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If you or someone you know has Depression and are between the ages of 18 and 65, you may be eligible for participation in research studies being conducted at the National Institute of Mental Health (NIMH).
NIMH researchers are conducting evaluations for medication studies (standard and novel antidepressants) and brain imaging studies. These evaluations include 1-4 visits, psychiatric interviews, medical history, physical exam, blood and other medical tests. These research studies are conducted in both outpatient and inpatient settings at the NIH Clinical Center in Bethesda, Maryland. Participants must be free of other serious medical conditions. Research evaluations and medications are provided at no cost. Additionally, we will cover transportation costs from anywhere in the U.S. Compensation is provided for research procedures and brain imaging.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov. (TTY: 1-866-411-1010) Atendemos pacientes de habla hispana.
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Disease and Treatment Information |
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Depression (Adult) Research Study
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5. NIMH Family Study of Health and Behavior
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The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.
We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors.
To find out if you qualify or for more information, please call 1-877-250-1560 or email at familystudy@mail.nih.gov.
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Depression (Adult) Research Study
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6. Depression & NR2A/B
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If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a National Institute of Mental Health research study investigating a novel medication. This treatment study is studying if a research medication can produce a rapid reduction of depressive symptoms in patients with treatment-resistant major depressive disorder. This 7-week inpatient study is conducted at the NIH Clinical Center in Bethesda, Maryland, and compares the medication to a placebo (inactive salt solution).
If you are 18-65 years of age and have been diagnosed with major depression and have taken two antidepressants that did not help, you may be eligible for this clinical trial.
Research evaluations and medications are provided at no cost. Transportation reimbursement is covered from anywhere in the United States.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644)(TTY: 1-866-411-1010) or moodresearch@mail.nih.gov
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Depression (Adult) Research Study
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7. Understanding Chemical Changes in the Brain after Depression Treatment
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If you (or someone you know) have been diagnosed with major depression, you may be eligible to participate in an NIMH research study. The scientific aims of the study are to measure levels of the neurotransmitter glutamate in the brain before and after antidepressant treatment and to compare these changes to treatment outcome. This is an 8-week outpatient research study in Bethesda, MD. Eligibility Criteria: 25 - 55 years of age; currently in an episode of Major Depressive Disorder; and are otherwise medically healthy. Research evaluations and medications are provided at no cost. Compensation is provided for portions of the study. After completion of the study, NIMH will provide short-term follow-up care, and then you will return to the care of your own provider. To find out if you qualify or for more information, please call 301-451-7214 or email us at depression@mail.nih.gov (TTY: 1-866-411-1010). Atendemos pacientes de habla hispana.
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Obsessive-Compulsive Disorder (Adult) Research Study
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1. OCD Sibling Study (Adult)
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We are examining the causes of Obsessive-Compulsive Disorder (OCD) by looking at the relationship between OCD, the brain, and genetic factors. We are enrolling sibling pairs (ages 18-55) where one sibling has the diagnosis of OCD and the other does not. Siblings must be full siblings (same mother and father).
The 1-day study involves a structured psychiatric interview, psychological testing, a Magnetic Resonance Imaging (MRI) scan, and a brief blood draw. Financial compensation and travel assistance is provided.
To find out if you qualify or for more information, please call 301-496-0851 or toll-free at 888-254-3823 or email us at sharpw@mail.nih.gov.
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Phantom Limb Pain Research Study
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1. Phantom Limb Pain Research Study
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Many amputees experience pain in their missing limb (often called phantom limb pain). One treatment for phantom limb pain is mirror therapy where the amputee views their moving intact limb in a mirror, making it seem as if it is the missing limb.
We are recruiting participants with an amputated limb to come to our main campus in Bethesda, MD, to participate in a brain imaging study during the course of mirror therapy. The goal of this study is to understand how the mirror therapy works: what parts of the brain are affected by the amputation, and how does the mirror therapy reverse those changes. Participants must be 18-75 years of age with a single amputated limb (not arising from diabetes). The study will require up to four visits to the campus, and participants will be reimbursed for their time participating in the study.
To find out if you qualify or for more information, please call 301-402-7511 or e-mail us at elkisv@mail.nih.gov .
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Schizophrenia (Adult) Research Study
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1. The NIMH Genetic Study of Schizophrenia
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If you or someone in your family is 18 years old or older and has been diagnosed with schizophrenia or schizoaffective disorder (depressed type), you may be able to participate in a genetic study that looks for genes in families. In order for family members to participate, the person with schizophrenia must be willing and able to participate. Eligible family members participate in an interview and contribute a sample of blood for genetic analysis. If you have schizophrenia, and if possible, your sibling, you may qualify to participate in this study. There is no change in medication involved.
The study involves simple cognitive tests and some MRI scans (no radiation). All testing is completed free of charge and there is compensation for each family member's participation in the study. Travel and lodging assistance is also available.
Scientists believe that the identification of susceptibility genes is key to understanding the molecular pathways of this disease so that better treatments and preventive methods can be developed in the future.
To find out if you qualify or for more information, please call 301-435-8970 (1-888-674-6464) or email us at schizophrenia@mail.nih.gov.
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Schizophrenia (Adult) Research Study
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2. Clinical Trial of Tolcapone for Cognition in Schizophrenia
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Are you having difficulty with your concentration? Are you between 18 and 50 years of age? If you have also received the diagnosis of schizophrenia or schizoaffective disorder, then you may be able to participate in a brief clinical trial assessing the effectiveness of a medication named tolcapone on your ability to concentrate, remember, and solve problems. During the study, you will be asked to stay at the NIH Clinical Center so the effects of this medication can be carefully monitored. Tolcapone will be administered along with the medication that you are currently taking. To enable us to examine how this medication affects your brain function and metabolism, you will be asked to undergo physical evaluations, no radioactive brain scans, and paper and pencil tests. This study also includes healthy volunteers.
To find out if you qualify or for more information, please call 301-435-8970 (1-888-674-6464)or email us at schizophrenia@mail.nih.gov.
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Schizophrenia (Adult) Research Study
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3. Clinical Trial of Modafinil for Cognition in Schizophrenia
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Are you having difficulty with your concentration? Are you between 18 and 50 years of age? If you have also received the diagnosis of schizophrenia or schizoaffective disorder, then you may be able to participate in a brief clinical trial assessing the effectiveness of a medication named modafinil on your ability to concentrate, remember, and solve problems. During the study, you will be asked to stay at the NIH Clinical Center so the effects of this medication can be carefully monitored. Modafinil will be administered along with the medication that you are currently taking. To enable us to examine how this medication affects your brain function and metabolism, you will be asked to undergo physical evaluations, no radioactive brain scans, and paper and pencil tests. This study also includes normal volunteers.
To find out if you qualify or for more information, please call 301-435-8970 (1-888-674-6464) or email us at schizophrenia@mail.nih.gov.
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Schizophrenia (Adult) Research Study
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4. Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 3.0 Tesla MRI and Magnetoencephalography
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If you have been diagnosed with schizophrenia or another neurological or neuropsychiatric disorder, you may be eligible to participate in this study. Its purpose is to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers. This study will use magnetic resonance imaging (MRI) scans to identify abnormalities in neurophysiology, neurochemistry and neuroanatomy that characterize schizophrenia and other disorders. More specifically, we hope to clarify the neuronal changes that occur in localized regions of the brain which may result in widespread, devastating consequences.
Healthy volunteers who have no history of psychiatric or major medical illness will also be enrolled in this study.
To find out if you qualify or for more information, please call 301-435-8970 (1-888-674-6464) or email us at schizophrenia@mail.nih.gov.
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Schizophrenia (Adult) Research Study
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5. A Study of Schizophrenia and the Brain: A Six-month Inpatient Evaluation Study
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Have you been diagnosed with schizophrenia or schizoaffective disorder? Are you between 18 and 55 years of age? Would you be willing to live at the Clinical Center on the NIH campus for six months? If so, you may be eligible to participate in a study designed to understand the neurological basis of schizophrenia and to determine which symptoms are related to the illness and which are related to the medications used to treat the illness.
This six-month study has three phases: In the first phase you will participate in many comprehensive medical, neurological, cognitive, and psychiatric evaluations. In the second phase, the research phase, you will be tapered off of your medication for about 4 weeks. In the time that your medication is discontinued, research procedures will allow investigators to distinguish the effects of the illness on the brain without the interference of the medication's effects. In the third phase, you will have the opportunity to stabilize using the treatment selected to be most helpful to you.
To find out if you qualify or for more information, please call 301-435-8970 (1-888-674-6464) or email us at schizophrenia@mail.nih.gov.
If you are interested in inpatient studies of shorter duration that do not require that you stop taking medication, please ask about the Tolcapone and Modafinil studies of schizophrenia and short-term memory.
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