Depression (Adult) Research Study
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1. Rapid Antidepressant Effects of Ketamine
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If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.
If you are 18-65 years of age and have been diagnosed with major depression (unipolar) and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.
After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov.
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Protocol Information |
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Depression (Adult) Research Study
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2. Depression & Scopolamine
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NIMH researchers are conducting an inpatient or outpatient treatment study to look at how a currently FDA-approved drug, Scopolamine, which is used for motion sickness, can help with depression. In this study, the drug is given intravenously over 7-sessions.
Eligibility criteria: Ages 18-55, currently depressed, not taking medications for at least 3 weeks.
After completion of the study, NIMH will provide short-term follow-up care, and then you will return to the care of your own provider. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States.
To find out if you qualify or for more information, please call 1-877-269-5586 or email us at moodresearch@mail.nih.gov (TTY: 1-866-411-1010). Atendemos pacientes de habla hispana.
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Disease and Treatment Information |
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Depression (Adult) Research Study
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3. Depression & Citalopram
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The scientific aims of the study are to compare blood cell levels of the p11 protein (which affects serotonin receptors) in depressed verses non-depressed individuals. We would like to examine the effect of citalopram, a selective serotonin reuptake inhibitor, on p11 levels in relation to treatment outcome.
This is a 10-12 week outpatient research study in Bethesda, MD. Eligibility Criteria: 18 - 65 years of age; currently in an episode of Major Depressive Disorder or have never experienced depression in the past; and are otherwise medically healthy. Research evaluations and medications are provided at no cost. Local transportation can be provided. After completion of the study, NIMH will provide short-term follow-up care, and then you will return to the care of your own provider.
To find out if you qualify or for more information, please call1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov (TTY: 1-866-411-1010). Atendemos pacientes de habla hispana.
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Disease and Treatment Information |
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Depression (Adult) Research Study
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4. Evaluations for Treatment and Brain Imaging Studies in Unipolar Depression
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If you or someone you know has Depression and are between the ages of 18 and 65, you may be eligible for participation in research studies being conducted at the National Institute of Mental Health (NIMH).
NIMH researchers are conducting evaluations for medication studies (standard and novel antidepressants) and brain imaging studies. These evaluations include 1-4 visits, psychiatric interviews, medical history, physical exam, blood and other medical tests. These research studies are conducted in both outpatient and inpatient settings at the NIH Clinical Center in Bethesda, Maryland. Participants must be free of other serious medical conditions. Research evaluations and medications are provided at no cost. Additionally, we will cover transportation costs from anywhere in the U.S. Compensation is provided for research procedures and brain imaging.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov. (TTY: 1-866-411-1010) Atendemos pacientes de habla hispana.
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Disease and Treatment Information |
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Depression (Adult) Research Study
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5. NIMH Family Study of Health and Behavior
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The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.
We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors.
To find out if you qualify or for more information, please call 1-877-250-1560 or email at familystudy@mail.nih.gov.
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Protocol Information |
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Depression (Adult) Research Study
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6. Depression & NR2A/B
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If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a National Institute of Mental Health research study investigating a novel medication. This treatment study is studying if a research medication can produce a rapid reduction of depressive symptoms in patients with treatment-resistant major depressive disorder. This 7-week inpatient study is conducted at the NIH Clinical Center in Bethesda, Maryland, and compares the medication to a placebo (inactive salt solution).
If you are 18-65 years of age and have been diagnosed with major depression and have taken two antidepressants that did not help, you may be eligible for this clinical trial.
Research evaluations and medications are provided at no cost. Transportation reimbursement is covered from anywhere in the United States.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644)(TTY: 1-866-411-1010) or moodresearch@mail.nih.gov
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Disease and Treatment Information |
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Depression (Adult) Research Study
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7. Understanding Chemical Changes in the Brain after Depression Treatment
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If you (or someone you know) have been diagnosed with major depression, you may be eligible to participate in an NIMH research study. The scientific aims of the study are to measure levels of the neurotransmitter glutamate in the brain before and after antidepressant treatment and to compare these changes to treatment outcome. This is an 8-week outpatient research study in Bethesda, MD. Eligibility Criteria: 25 - 55 years of age; currently in an episode of Major Depressive Disorder; and are otherwise medically healthy. Research evaluations and medications are provided at no cost. Compensation is provided for portions of the study. After completion of the study, NIMH will provide short-term follow-up care, and then you will return to the care of your own provider. To find out if you qualify or for more information, please call 301-451-7214 or email us at depression@mail.nih.gov (TTY: 1-866-411-1010). Atendemos pacientes de habla hispana.
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Disease and Treatment Information |
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