NIH Text
NIMH logo image and link
Building 35 Image Division of Intramural Research Programs image
     
  Patient Recruitment - Irritability
 

Research Studies        
1. Clinical Trial of Citalopram and Methylphenidate in Severe Mood Dysregulation   2. A Study of Brain Function and Symptoms in Children with Severe Mood Dysregulation   Seminar: What Professionals Need to Know About Irritability, Bipolar Disorder and Disruptive Mood Dysregulation in Children

Irritability (Pediatric) Research Study

1. Clinical Trial of Citalopram and Methylphenidate in Severe Mood Dysregulation

This study is testing the effectiveness of methylphenidate plus citalopram vs. methylphenidate plus placebo for decreasing irritability in children with severe mood dysregulation (SMD). Children with SMD display chronic anger, sadness, or irritability, as well as hyperarousal (such as insomnia, distractibility, hyperactivity) and extreme responses to frustration (such as frequent, severe temper tantrums).

Children ages seven to 17 with SMD may be eligible to participate in this 12- to 15-week inpatient or outpatient study. This study has four phases. During Phase I participants are gradually withdrawn from all current psychotropic medications. Phase II is a one-week psychotropic medication-free period. During Phase III, which lasts two weeks, participants are treated with methylphenidate alone. Phase IV lasts for eight weeks. During this time, participants continue methylphenidate treatment and are randomly assigned to also receive either citalopram or placebo.

At the end of the study, those who received methylphenidate plus placebo will have the opportunity to receive methylphenidate plus active citalopram if clinically appropriate.

All procedures and medications associated with the research are provided at no cost to participants, and transportation expenses are reimbursed by NIMH. Schooling will be provided while on the inpatient unit or in day treatment.

To find out if you qualify or for more information, please call (301) 496-8381 or email us at irritablekids email.
 
Email This Study To A Friend       View/Print PDF Version Of This Study

Disease and Treatment Information
 

 

Irritability (Pediatric) Research Study

2. A Study of Brain Function and Symptoms in Children with Severe Mood Dysregulation

This study seeks to learn more about the symptoms of severe mood dysregulation in children and adolescents ages 7-17. Children and adolescents with severe mood dysregulation (SMD) display chronic anger, sadness, or irritability, as well as hyperarousal (such as insomnia, distractibility, hyperactivity) and extreme responses to frustration (such as frequent, severe temper tantrums). Researchers will describe the moods and behaviors of children with these symptoms and use specialized testing and brain imaging to learn about the brain changes associated with this disorder.

Study participation begins with an initial outpatient evaluation that lasts one day. Then, testing and brain imaging are completed at two-three day outpatient visits which occur every two years until participants reach age 25. Phone contact occurs every six months in between visits.

Descriptive/Longitudinal Study: When children have severe mood dysregulation (SMD), do their brains work differently than those of other children? How do their symptoms change as the children grow up?

After a preliminary phone interview, participants may be invited to NIMH for an on-site assessment. Children must be in treatment with a psychiatrist or provider, and/or medically healthy and not currently hospitalized, psychotic or suicidal.

A principal focus of the research is how mood, behavior, and brain development of children with severe mood dysregulation (SMD) change over time. Study procedures at the two-three day visits may include questionnaires and interviews; paper-and-pencil and computer tests of mood, memory, and thinking; specialized computer games; and structural and functional Magnetic Resonance Imaging (MRI) scans. These visits occur every two years until age 25. Children continue in treatment with a provider or psychiatrist in their community. This study does not involve treatment medications.

To find out if you qualify, or for more information, please call (301) 496-8381 or email us at irritablekids email.
 
Email This Study To A Friend       View/Print PDF Version Of This Study

Disease and Treatment Information
 

 

Irritability (Pediatric) Research Study

Seminar: What Professionals Need to Know About Irritability, Bipolar Disorder and Disruptive Mood Dysregulation in Children

March 28, 2014, 9am-12pm

Join expert Dr. Kenneth Towbin, M.D., Child & Adolescent Psychiatrist at NIMH, for an in-depth discussion of pediatric bipolar disorder, severe mood dysregulation, and the new DSM.5 diagnosis Disruptive Mood Dysregulation Disorder (DMDD). Through the lens of the latest research, participants will explore the challenging symptom presentations seen in children diagnosed with these disorders. Professionals will have the opportunity to compare disorders through case presentations, and discuss diagnostic considerations and effective assessment tools. A review and dialogue of pharmacological and non-pharmacological interventions will follow.

Participants will learn to: Recognize the differences between and nuances of Bipolar Disorder, Severe Mood Dysregulation, and Disruptive Mood Dysregulation in children and adolescents; Understand, identify, and distinguish disorders that commonly display symptoms of irritability in children; Discuss assessment tips and guidelines when working with children with these disorders and their families; Explore treatment implications for these disorders.

3 Category I CEU credits are available for social workers licensed in Maryland. Certificates of attendance will be provided for participants. This event is free and open to the public. Seating is limited.

About the Presenter: Dr. Towbin is Chief of Clinical Child and Adolescent Psychiatry in the Emotion and Development Branch at the National Institute of Mental Health Intramural Research Program. The group with which he is affiliated focuses its research on identifying and treating childhood bipolar disorder and severe irritability in children. His interests include emotional dysregulation in children and adolescents, bipolar disorder, tic disorders, obsessive compulsive disorder, and pervasive developmental disorders.

Location: Johns Hopkins University- Montgomery County Campus, 9601 Medical Center Drive, A & R Building, Room 106-110, Rockville, MD. Directions and Parking information: http://mcc.jhu.edu/about/directions.

To Register: Contact Kalene DeHaut, MSW at kalene.dehaut email with your name, phone number, and social work licensure level (if applicable) before 3/14/2014.
 
Email This Study To A Friend       View/Print PDF Version Of This Study

 

 
 

NIMH HOME · COPYRIGHT · POLICIES · FOIA · SITE MAP · STAFF DIRECTORIES · EMPLOYMENT OPPORTUNITIES · PRIVACY NOTICE · ACCESSIBILITY · RECRUITMENT CONTACT

"NIH…Turning Discovery into Health”